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Anti-MAPT PHOSPHO Antibody EPR2402
Also for MAPT (NM_016841)
|A phospho-specific peptide corresponding to residues on human Tau was used as an immunogen. The antibody only detects Tau phosphorylated on Serine 202.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:5000 - 1:10000; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 4|
|DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU|
|Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).|
MAPK signaling pathway
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Western blot - Tau (phospho S202) antibody [EPR2402]; All lanes : Anti-Tau (phospho S202) antibody [EPR2402] at 1/10000 dilution.Lane 1 : SH SY5Y cell lysate, untreated.Lane 2 : SH SY5Y cell lysate treated with Alkaline Phosphatse.Lysates/proteins at 10 µg per lane.Predicted band size : 79 kDa.