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Home Antibody All anti-TUBA1B antibodies

Anti-TUBA1B Antibody EPR1333

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307175
  • Rabbit monoclonal antibody against Alpha-Tubulin(clone EPR1333)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401831) , 20ug
100ul 325 In Stock
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WB(1)
IHC(2)
IF(1)
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Also for TUBA1B (NM_006082)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Alpha-Tubulin was used as an immunogen.
Clone NameEPR1333 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:500 - 1:1000; FC: 1:10 - 1:100; ICC/IF: 1:250 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens tubulin, alpha 1b (TUBA1B)
Alternative NameK-ALPHA-1
Database LinkNP_006073
FunctionMicrotubules are essential to eukaryotic cytoskeletal structures, vesicular transportation, and mitosis. It consists mainly of two soluble protein subunits, alpha- and beta-tubulin. Alpha-tubulin binds to beta-tubulin to form a heterodimer that is subject to post-translation modifications (1). The tubulin dimer complex binds to GTP and assembles onto the positive ends of microtubules. After incorporation into the microtubules, bound GTP is hydrolyzed by beta-tubulin, but not alpha-tubulin. The stability of the dimer in the microtubules is dependent on the presence of beta-tubulin, since the dimer with GTP bound beta-tubulin is stable in microtubule integration (2). For both types of tubulins, the carboxy-terminal tail is post-translationally modified to regulate associated protein binding at the microtubule surface (3). Defects in alpha-tubulin are the cause of lissencephaly type 3 (LIS3), characterized by agyria (4).
Related Pathway
Cell cycle

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - TUBA1B antibody [EPR1333]; All lanes : Anti-TUBA1B antibody [EPR1333] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : 293T cell lysate.Lane 4 : A431 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 50 kDa.Observed band size : 50 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TUBA1B antibody [EPR1333]; TA307175, at 1/500 dilution, staining TUBA1B in paraffin embedded Human placenta tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TUBA1B antibody [EPR1333]; TA307175, at a 1/500 dilution, staining TUBA1B in paraffin embedded Human breast tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - TUBA1B antibody [EPR1333]; TA307175, at a 1/250 dilution, staining TUBA1B in HeLa cells by Immunofluorescence.

 

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