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Home Antibody All anti-NEFL antibodies

Anti-NEFL Antibody EPR2459(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307174
  • Rabbit monoclonal antibody against Neurofilament L(clone EPR2459(2))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC416829) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for NEFL (NM_006158)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Neurofilament L was used as an immunogen.
Clone NameEPR2459(2) IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

Reference Data

Target NameHomo sapiens neurofilament, light polypeptide (NEFL)
Alternative NameCMT1F; CMT2E; NF-L; NF68; NFL
Database LinkNP_006149
FunctionNeurofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins; NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). NF-L self polymerizes and provides a scaffold for NFs to form via cross-bridging with NF-H or NF-M (3). NF-L aggregation has been linked to the pathogenesis of neurodegenerative disease, such as degradation of motor neurons (4).
Related Pathway

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WB Image
Western blot - 70 kD Neurofilament Light antibody [EPR2459(2)]; All lanes : Anti-70 kD Neurofilament Light antibody [EPR2459(2)] at 1/1000 dilution.Lane 1 : C6 cell lysate .Lane 2 : Human Fetal brain cell lysate.Lane 3 : HeLa cell lysate .Lysates/proteins at 10 µg per lane.Predicted band size : 62 kDa.Observed band size : 68 kDa .

 

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