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Anti-NEFL Antibody EPR2459(2)
Also for NEFL (NM_006158)
|A synthetic peptide corresponding to residues in human Neurofilament L was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
|Homo sapiens neurofilament, light polypeptide (NEFL)|
|CMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110|
Entrez Gene 4747 Human
Entrez Gene 18039 Mouse
Entrez Gene 83613 Rat
|Neurofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins; NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). NF-L self polymerizes and provides a scaffold for NFs to form via cross-bridging with NF-H or NF-M (3). NF-L aggregation has been linked to the pathogenesis of neurodegenerative disease, such as degradation of motor neurons (4).|
|ES Cell Differentiation/IPSDruggable Genome Amyotrophic lateral sclerosis (ALS)|
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Western blot - 70 kD Neurofilament Light antibody [EPR2459(2)]; All lanes : Anti-70 kD Neurofilament Light antibody [EPR2459(2)] at 1/1000 dilution.Lane 1 : C6 cell lysate .Lane 2 : Human Fetal brain cell lysate.Lane 3 : HeLa cell lysate .Lysates/proteins at 10 ug per lane.Predicted band size : 62 kDa.Observed band size : 68 kDa .