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Anti-PTGES3 Antibody EPR3846
Also for PTGES3 (NM_006601)
|A synthetic peptide corresponding to residues in human Prostaglandin E Synthase 3 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||ICC: 1:100 - 250, IP: 1:50, WB: 1:10,000 - 50,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens prostaglandin E synthase 3 (cytosolic) (PTGES3), transcript variant 1|
|cPGES; P23; TEBP|
|Prostaglandin E synthase-3 belongs to p23/wos2 family. It is ubiquitously expressed. As one of the two isoforms of the terminal enzymes catalyzing the final step of EG2 biosynthesis, prostaglandin E synthase-3 predominantly converts COX-1-derived PGH2 to PGE2 (1). It is an evolutionarily conserved protein that functions as a component of the Hsp90-based molecular chaperone complex (2). It binds to telomerase and to the progesterone receptor (3). It localizes to genomic response elements in a hormone-dependent manner and represses receptor-mediated transcriptional activation by promoting disassembly of transcriptional regulatory complexes (4). |
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Western blot - p23 antibody [EPR3846]; All lanes : Anti-p23 antibody [EPR3846] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Human spleen lysate.Lane 3 : Jurkat cell lysate.Lane 4 : HepG2 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP-labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 19 kDa.Observed band size : 23 kDa .
Immunocytochemistry/ Immunofluorescence - p23 antibody [EPR3846]; Immunofluorescent staining of HeLa cells, using ab92503 at a dilution of 1/100.