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Anti-HSPH1 Antibody EPR4577


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against HSP105(clone EPR4577)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402001) , 20ug Explanation
100ul $325 3-7 Days
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Also for HSPH1 (NM_006644)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human HSP105 was used as an immunogen.
Clone NameEPR4577 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens heat shock 105kDa/110kDa protein 1 (HSPH1), transcript variant 1
Alternative NameHSP105; HSP105A; HSP105B; NY-CO-25
Database LinkNP_006635
Entrez Gene 10808 Human
FunctionHSP105α and HSP105beta are mammalian members of the HSP105/110 family, a diverged subgroup of the HSP70 family (1). It has been reported that two isoforms of HSP105 (HSP105α and HSP105beta) were both moderately expressed in adrenal, spleen, liver and heart, and both increased markedly after heat shock. However, in brain HSP105α was characteristically highly expressed over HSP105beta, but neither increased after heat shock (2). HSP105 prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly, and it inhibits HSPA8/HSC70 ATPase and chaperone activities (3).
Related PathwayStem cell - Pluripotency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Hsp105 antibody [EPR4577]; All lanes : Anti-Hsp105 antibody [EPR4577] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 97 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Hsp105 antibody [EPR4577]; TA307150 at 1/100 dilution staining Hsp105 in Human testis by Immunohistochemistry, Paraffin-embedded tissue.
Immunocytochemistry/ Immunofluorescence - Hsp105 antibody [EPR4577]; TA307150 at 1/100 dilution staining Hsp105 in HeLa cells by Immunofluorescence.


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