SynGAP is a neuron-specific Ras GTPase-activating protein found in high concentration in the postsynaptic density fraction from mammalizn forebrain (1). It is a major constituent of the post synaptic density (PSD) a complex of protein that colocalize with NMDA receptors at synapses. SynGAP is phosphorylated by Ca2+/calmodulin-dependent-kinases (CaMKII) at Ser123.
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