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Anti-MALT1 Antibody EPR604


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against MALT1 / MLT1(clone EPR604)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402030) , 20ug Explanation
100ul $325 3-7 Days
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Also for MALT1 (NM_006785)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MALT1 / MLT1 was used as an immunogen.
Clone NameEPR604 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:250 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 1
Alternative NameIMD12; MLT; MLT1
Database LinkNP_006776
Entrez Gene 10892 Human
FunctionMucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, MALT1 synergizes with Bcl-10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitination of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin's B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5).
Related PathwayProteaseDruggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - MALT1 antibody [EPR604]; All lanes : Anti-MALT1 antibody [EPR604] at 1/1000 dilution.Lane 1 : Jurkat lysate.Lane 2 : K562 lysate.Lane 3 : Bone marrow lysate.Lane 4 : PBMC lysates.Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 92 kDa.


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