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Anti-MALT1 Antibody EPR604
Also for MALT1 (NM_006785)
|A synthetic peptide corresponding to residues in human MALT1 / MLT1 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC: 1:250 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 1|
|IMD12; MLT; MLT1|
Entrez Gene 10892 Human
|Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, MALT1 synergizes with Bcl-10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitination of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin's B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5).|
|ProteaseDruggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway|
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Western blot - MALT1 antibody [EPR604]; All lanes : Anti-MALT1 antibody [EPR604] at 1/1000 dilution.Lane 1 : Jurkat lysate.Lane 2 : K562 lysate.Lane 3 : Bone marrow lysate.Lane 4 : PBMC lysates.Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 92 kDa.