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Anti-KIF22 Antibody EP2748


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against KIF22(clone EP2748)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416047) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human KIF22 was used as an immunogen.
Clone NameEP2748 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens kinesin family member 22 (KIF22), transcript variant 1
Alternative NameA-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2; SEMDJL2
Database LinkNP_015556
Entrez Gene 3835 Human
FunctionKIF22 (KNSL4; kinesin-like DNA-binding protein) is a member of the kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis (1). KIF22 colocalizes with mitotic chromosomes and is enriched in the kinetochore at anaphase. It might play a role in regulating the chromosomal movement along microtubules during mitosis. The N-terminal region of KIF22 shares greater than 35% sequence homology with the motor domains of other kinesins. The C-terminal domain has limited but significant homology to NOD, a Drosophila protein and member of the kinesin family. KIF22 also contains a putative nuclear localization signal (2). It was demonstrated that SIAH, a human homologue of the Drosophila seven in absentia (Sina), is involved in the degradation of KIF22 via the ubiquitin-proteasome pathway (3).
Related PathwayDruggable Genome

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Western blot - KIF22 antibody [EP2748]; All lanes : Anti-KIF22 antibody [EP2748] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : SH-SY5Y cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 73 kDa.


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