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Anti-TBK1 PHOSPHO Antibody EPR2867(2)


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SKU Description Amount Price Availability*  
TA307115 Rabbit monoclonal antibody against NAK/TBK1 Phospho (pS172)(clone EPR2867(2)) (Phospho-Specific) 100ul $325 In Stock
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 172 of human NAK/TBK1 was used as an immunogen. This antibody only detects NAK/TBK1 phosphorylated at serine 172.
Clone NameEPR2867(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
Predicted MW Explanation 84 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens TANK-binding kinase 1 (TBK1)
Alternative NameNAK; T2K
Database LinkNP_037386
Entrez Gene 29110 Human
Entrez Gene 56480 Mouse
Entrez Gene 299827 Rat
FunctionNFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor−associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumor promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).
Related PathwayProtein KinaseDruggable Genome Toll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - NAK (phospho S172) antibody [EPR2867(2)]; All lanes : Anti-NAK (phospho S172) antibody [EPR2867(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate, treated with Calyculin A.Lysates/proteins at 10 ug per lane.Predicted band size : 84 kDa.


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