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Anti-TAC1 Antibody EPR3959

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307112
  • Rabbit monoclonal antibody against Substance P(clone EPR3959)
100ul 325 3-7 Days
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IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Substance P was used as an immunogen.
Clone NameEPR3959 IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *IHC Suggested DilutionsIHC-P: 1:50 - 1:100
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IP or WB.

Reference Data

Target NameHomo sapiens tachykinin, precursor 1 (TAC1), transcript variant beta
Alternative NameHs.2563; NK2; NKNA; NPK; TAC2
Database LinkNP_003173
FunctionSubstance P, an 11-amino acid peptide, is part of the tachykinin peptide hormone family that includes neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma (1,2). These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells (1). Substance P is normally present at relatively high concentrations in nerve endings in selected regions of the mammalian brain. It is present in dorsal root ganglion (primary sensory) neurons and has been functionally linked to pain. The specific receptor subtype that corresponds to substance P is neurokinin 1 receptors, and this neurotransmitter appears to play a key role in the regulation of emotions (3).
Related Pathway
Signaling by GPCR

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IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Substance P antibody [EPR3959]; Immunohistochemical analysis of Substance P in paraffin embedded Human brain tissue, using TA307112 at a 1/50 dilution.

 

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