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Home Antibody All anti-BCAR1 antibodies

Anti-BCAR1 Antibody EPR1850(2)

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307103 Rabbit monoclonal antibody against p130Cas(clone EPR1850(2)) 100ul $325 3-7 Days
LC415204 BCAR1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for BCAR1 (NM_014567)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human p130Cas was used as an immunogen.
Clone NameEPR1850(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 93 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6
Alternative NameCAS; CAS1; CASS1; CRKAS; P130Cas
Database LinkNP_055382
Entrez Gene 9564 Human
Entrez Gene 12927 Mouse
Entrez Gene 25414 Rat
FunctionBreast cancer anti-estrogen resistance protein 1 (p130Cas) is a docking protein that plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (1). It has a defined function in cardiovascular development, actin filament assembly and Src-induced transformation (2). p130Cas is highly phosphorylated at tyrosines during transformation by v-Src, as well as by v-Crk, forming stable complexes with these oncoproteins. Cytoplasmic p130Cas has been shown to move to the membrane upon tyrosine phosphorylation. p130Cas is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins, and its unique structure indicates its possible role in assembling signals from multiple SH2-containing molecules (3). It is implicated in induction of cell migration, and over expression of p130Cas confers anti-estrogen resistance on breast cancer cells (1).
Related PathwayDruggable Genome Chemokine signaling pathwayFocal adhesionLeukocyte transendothelial migrationRegulation of actin cytoskeleton

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

 

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