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Home Antibody All anti-BCAR1 antibodies

Anti-BCAR1 PHOSPHO Antibody EPR1860

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307102
  • Rabbit monoclonal antibody against p130Cas Phospho (pY410) (clone EPR1860 ) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
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Also for BCAR1 (NM_014567)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Tyrosine 410 of human p130Cas was used as an immunogen.
Clone NameEPR1860 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsIP: 1:50, WB: 1:2,500 - 5,000,
Predicted MW Explanation 93 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6
Alternative NameCAS; CAS1; CASS1; CRKAS; P130Cas
Database LinkNP_055382
Entrez Gene 9564 Human
FunctionBreast cancer anti-estrogen resistance protein 1 (p130Cas) is a docking protein that plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (1). It has defined function in cardiovascular development, actin filament assembly and Src-induced transformation (2). p130Cas is highly phosphorylated at tyrosines during transformation by v-Src, as well as by v-Crk, forming stable complexes with these oncoproteins. Cytoplasmic p130Cas has been shown to move to the membrane upon tyrosine phosphorylation. p130Cas is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins, and its unique structure indicates its possible role in assembling signals from multiple SH2-containing molecules (3). It is implicated in induction of cell migration, and over expression of p130Cas confers anti-estrogen resistance on breast cancer cells (1).
Related PathwayDruggable Genome Chemokine signaling pathwayFocal adhesionLeukocyte transendothelial migrationRegulation of actin cytoskeleton

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - BCAR1 (phospho Y410) antibody [EPR1860]; All lanes : Anti-BCAR1 (phospho Y410) antibody [EPR1860] at 1/2500 dilution.Lane 1 : HeLa cell lysate untreated.Lane 2 : HeLa cell lysate treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP-labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 93 kDa.

 

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