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Anti-S100A6 Antibody EPNCIR121
Also for S100A6 (NM_014624)
| Human S100A6 recombinant protein was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for IHC-P.
|Homo sapiens S100 calcium binding protein A6 (S100A6)|
|2A9; 5B10; CABP; CACY; PRA|
|S100 Calcium-binding protein A6 (S100A6) is a member of the S100 family proteins containing two EF-hand calcium-binding motifs (1). S100 proteins play a role in the regulation of cell cycle progression, exocytosis, and cytoskeletal rearrangement (2). It interacts with calcyclin binding protein/Siah-1 interacting protein CacyBP/SIP, a subunit of an E3 ubiquitin ligase complex (1). CacpBP mediates the beta-catenin degradation pathway, which is essential for thymocyte development and cell-cycle progression (3). S100A6 blocks activation of the fetal gene program, e.g. skeletal α-actin and β-myosin heavy chain, and down-regulates the normal expression of the adult α-myosin heavy chain (4). Overexpression of S100A6 has been associated with higher mortality in pancreatic cancer (5).|
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Western blot - Anti-S100 alpha 6 antibody [EPNCIR121]; All lanes : Anti-S100 alpha 6 antibody [EPNCIR121] at 1/1000 dilution.Lane 1 : Fetal lung cell lysates.Lane 2 : A549 cell lysates.Lane 3 : Ovary cancer cell lysates.Lane 4 : SH-SY5Y cell lysates.Lane 5 : Human T-78 cell lysates.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 10 kDa.
Immunocytochemistry/ Immunofluorescence - Anti-S100 alpha 6 antibody [EPNCIR121]; Immunofluorescence analysis of HeLa cells labelled with ab134149 at 1/100 dilution.