S100 Calcium-binding protein A6 (S100A6) is a member of the S100 family proteins containing two EF-hand calcium-binding motifs (1). S100 proteins play a role in the regulation of cell cycle progression, exocytosis, and cytoskeletal rearrangement (2). It interacts with calcyclin binding protein/Siah-1 interacting protein CacyBP/SIP, a subunit of an E3 ubiquitin ligase complex (1). CacpBP mediates the beta-catenin degradation pathway, which is essential for thymocyte development and cell-cycle progression (3). S100A6 blocks activation of the fetal gene program, e.g. skeletal α-actin and β-myosin heavy chain, and down-regulates the normal expression of the adult α-myosin heavy chain (4). Overexpression of S100A6 has been associated with higher mortality in pancreatic cancer (5).
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