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Home Antibody All anti-NCSTN antibodies

Anti-NCSTN Antibody EPR2574

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307096
  • Rabbit monoclonal antibody against Nicastrin(clone EPR2574)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC414628) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for NCSTN (NM_015331)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Nicastrin was used as an immunogen.
Clone NameEPR2574 IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens nicastrin (NCSTN), transcript variant 1
Alternative NameATAG1874
Database LinkNP_056146
FunctionNicastrin, a transmembrane glycoprotein, is an essential component of the gamma-secretase complex that is required for the intramembrane proteolysis of an increasing number of membrane proteins, including the amyloid-beta precursor protein (APP) and Notch (1). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex (2). Nicastrin regulates gamma-secretase cleavage of the amyloid precursor protein by forming complexes with presenilins, in which most mutations causing familial early-onset Alzheimer's disease (EOAD) have been found (3).
Related Pathway
Delta-Notch Signaling Pathway

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WB Image
Western blot - Nicastrin antibody [EPR2574]; All lanes : Anti-Nicastrin antibody [EPR2574] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 78 kDa.

 

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