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Anti-NCSTN Antibody EPR2574
Also for NCSTN (NM_015331)
|A synthetic peptide corresponding to residues in human Nicastrin was used as an immunogen.|
|Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens nicastrin (NCSTN), transcript variant 1|
Entrez Gene 23385 Human
|Nicastrin, a transmembrane glycoprotein, is an essential component of the gamma-secretase complex that is required for the intramembrane proteolysis of an increasing number of membrane proteins, including the amyloid-beta precursor protein (APP) and Notch (1). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex (2). Nicastrin regulates gamma-secretase cleavage of the amyloid precursor protein by forming complexes with presenilins, in which most mutations causing familial early-onset Alzheimer's disease (EOAD) have been found (3).|
|TransmembraneDruggable Genome Notch signaling pathwayAlzheimer's disease|
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Western blot - Nicastrin antibody [EPR2574]; All lanes : Anti-Nicastrin antibody [EPR2574] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 78 kDa.