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Home Antibody All anti-NCSTN antibodies

Anti-NCSTN Antibody EPR2574

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307096
  • Rabbit monoclonal antibody against Nicastrin(clone EPR2574)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC414628) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for NCSTN (NM_015331)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Nicastrin was used as an immunogen.
Clone NameEPR2574 IsotypeIgG
Species ReactivityHuman (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
Predicted MW Explanation 78 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens nicastrin (NCSTN), transcript variant 1
Alternative NameATAG1874
Database LinkNP_056146
Entrez Gene 23385 Human
FunctionNicastrin, a transmembrane glycoprotein, is an essential component of the gamma-secretase complex that is required for the intramembrane proteolysis of an increasing number of membrane proteins, including the amyloid-beta precursor protein (APP) and Notch (1). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex (2). Nicastrin regulates gamma-secretase cleavage of the amyloid precursor protein by forming complexes with presenilins, in which most mutations causing familial early-onset Alzheimer's disease (EOAD) have been found (3).
Related PathwayTransmembraneDruggable Genome Notch signaling pathwayAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Nicastrin antibody [EPR2574]; All lanes : Anti-Nicastrin antibody [EPR2574] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 78 kDa.

 

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