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Anti-HIF1AN Antibody EPR3658


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against FIH1 (clone EPR3658 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402628) , 20ug Explanation
100ul $325 3-7 Days
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Also for HIF1AN (NM_017902)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human FIH1 was used as an immunogen.
Clone NameEPR3658 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsFC: 1:100, ICC: 1:100 - 250, IHC: 1:250 - 500, WB: 1:5,000 - 10,000,
Predicted MW Explanation 40 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens hypoxia inducible factor 1, alpha subunit inhibitor (HIF1AN)
Alternative NameFIH1
Database LinkNP_060372
Entrez Gene 55662 Human
FunctionFactor inhibiting HIF-1 (FIH1) is an Fe (II)-dependent hydroxylase enzyme that serves as an oxygen sensor in the hypoxia response pathway (1). FIH1 binds to HIF-1alpha and inhibits its transactivation function. It also binds to VHL, which too functions as a transcriptional corepressor that inhibits HIF-1alpha transactivation function (2). In addition, FIH1 regulates the Notch signaling output and plays a role in how Notch signaling modulates the hypoxic response. It negatively regulates Notch activity and accelerates myogenic differentiation (3).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - HIF1AN antibody; All lanes : Anti-HIF1AN antibody [EPR3658] at 1/5000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : 293T cell lysate.Lane 3 : A375 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 40 kDa.Observed band size : 40 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HIF1AN antibody [EPR3658]; TA307080 at 1/250 dilution staining HIF1AN in Human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HIF1AN antibody [EPR3658]; TA307080 at 1/250 dilution staining HIF1AN in Human brain by Immunohistochemistry, Paraffin-embedded tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - HIF1AN antibody [EPR3658]; TA307080 at 1/100 dilution staining HIF1AN in HeLa cells by Immunofluorescence.


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