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Home Antibody All anti-VTCN1 antibodies

Anti-VTCN1 Antibody EP1165

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307046
  • Rabbit monoclonal antibody against TFF3(clone EP1165)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403017) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenA peptide corresponding to residues near N-term of human GNB2 was used as an immunogen.
Clone NameEP1165 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:20; IHC-P: 1:250 - 1:500; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens V-set domain containing T cell activation inhibitor 1 (VTCN1), transcript variant 1
Alternative NameB7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291; VCTN1
Database LinkNP_078902
Entrez Gene 79679 Human
Entrez Gene 242122 Mouse
Entrez Gene 295322 Rat
FunctionAs a member of B7 family, B7-H4 (VTCN1) plays a critical role in the regulation of antigen-specific immune responses. B7-H4 is a co-stimulatory protein expressed in activated T cells and is involved in the negative regulation of cell-mediated immunity in peripheral tissues (1).B7-H4 ligation to its receptor BTLA T-lymphocytes results in inhibition of T-cell activation, cytokine secretion, and the development of cytotoxicity (2). B7-H4 protein is typically expressed on the surface of activated T-cells, B-cells, monocytes, and dendritic cells, but not in most normal tissues. In tissues, B7-H4 is over expressed in breast, endometrial, ovarian, renal cell (RCC), and non-small cell lung carcinomas (NSCLC). B7-H4 has been identified as an important cancer marker for breast and ovarian cancers.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - B7H4 antibody [EP1165]; All lanes : Anti-B7H4 antibody [EP1165] at 1/10000 dilution.Lane 1 : Human fetal spleen lysate.Lane 2 : Human fetal thymus lysate.Lane 3 : SKBR3 lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 31 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - B7H4 antibody [EP1165]; TA307046, at 1/250 dilution, staining B7H4 in paraffin-embedded Human tonsil tissue by Immunohistochemistry.

 

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