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Anti-C13orf34 Antibody EPR4456
Also for C13orf34 (NM_024808)
|A synthetic peptide corresponding to residues in human BORA was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens bora, aurora kinase A activator (BORA), transcript variant 1|
|BORA is an activator of protein kinase Aurora A, which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (1). It is also a Plk1-interacting protein, which controls multiple transitions in mitosis and cytokinesis. One of Plk1's key biochemical functions is to phosphorylate its substrates and to target them for degradation by the SCF-β-TrCP ubiquitin ligase in the cell cycle. Degradation of BORA after mitotic entry releases Plk1 free to associate with prime-phosphorylated substrates, which enhance its kinase activity and target Plk1 to kinetochores and centrosomes for its mitotic function (2).|
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Western blot - Bora antibody [EPR4456]; All lanes : Anti-Bora antibody [EPR4456] at 1/1000 dilution.Lane 1 : fetal brain lysate.Lane 2 : SH-SY5Y lysate.Lane 3 : Y79 lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 61 kDa.