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Home Antibody All anti-C13orf34 antibodies

Anti-C13orf34 Antibody EPR4456

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307043
  • Rabbit monoclonal antibody against BORA(clone EPR4456)
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human BORA was used as an immunogen.
Clone NameEPR4456 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
Predicted MW Explanation 61 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens bora, aurora kinase A activator (BORA), transcript variant 1
Alternative NameC13orf34
Database LinkNP_079084
Entrez Gene 79866 Human
Entrez Gene 77744 Mouse
Entrez Gene 306102 Rat
FunctionBORA is an activator of protein kinase Aurora A, which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (1). It is also a Plk1-interacting protein, which controls multiple transitions in mitosis and cytokinesis. One of Plk1's key biochemical functions is to phosphorylate its substrates and to target them for degradation by the SCF-β-TrCP ubiquitin ligase in the cell cycle. Degradation of BORA after mitotic entry releases Plk1 free to associate with prime-phosphorylated substrates, which enhance its kinase activity and target Plk1 to kinetochores and centrosomes for its mitotic function (2).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Bora antibody [EPR4456]; All lanes : Anti-Bora antibody [EPR4456] at 1/1000 dilution.Lane 1 : fetal brain lysate.Lane 2 : SH-SY5Y lysate.Lane 3 : Y79 lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 61 kDa.

 

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