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Anti-PLXNA1 Antibody EPR3449


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Plexin-A1 (clone EPR3449 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC410263) , 20ug Explanation
100ul $325 3-7 Days
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Also for PLXNA1 (NM_032242)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Plexin-A1 was used as an immunogen.
Clone NameEPR3449 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsFC: 1:50, ICC: 1:100, WB: 1:1000 - 2000,
Predicted MW Explanation 211 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens plexin A1 (PLXNA1)
Alternative NameNOV; NOVP; PLEXIN-A1; PLXN1
Database LinkNP_115618
Entrez Gene 5361 Human
Entrez Gene 18844 Mouse
Entrez Gene 362398 Rat
FunctionPlexins are large transmembrane receptors for semaphorins. It contains a sema domain and a highly conserved cytoplasmic domain (1). Plexins are classified into four groups: A, B, C, D. Plexin-A1 is a co-receptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. It is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plexin-A1 plays a role in axon guidance, invasive growth and cell migration. Plexin-A1 modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (2). Plexin-A1 is specific in fetal brain, lung, liver and kidney (3).
Related PathwayTransmembraneDruggable Genome Axon guidance

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Plexin A1 antibody [EPR3449]; All lanes : Anti-Plexin A1 antibody [EPR3449] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : HUVEC cell lysate.Lane 4 : HepG2 cell lysate.Lane 5 : Fetal brain tissue lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit antibody at 1/2000 dilution.Predicted band size : 211 kDa.


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