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Anti-C17orf37 Antibody EPR2678
Also for C17orf37 (NM_032339)
|A synthetic peptide corresponding to residues in human C35 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens migration and invasion enhancer 1 (MIEN1)|
|C17orf37; C35; ORB3; RDX12; XTP4|
|C35 (C17orf37, XTP4, ORB3) is a novel cancer marker encoded by a gene located on chromosome 17, adjacent to the Her2 oncogene. Similar to Her2, C35 is overexpressed in cancer tissues, in particular breast and prostate cancer tissues, but not in the normal homolog tissues. The functional role of C35 has not been identified. However, an analysis of predicted functional motifs of the gene product suggests it may play role in signal transduction and redox-related process (1). In prostate cancer, the downregulation of C35 lead to suppression of both Akt phospholyation and NF-kappa B activity. This suggests C35 might be involved in increasing the invasive potential of prostate cancer cells by NF-kappaB-mediated downstream target genes (2). Along with its tumor specific expression, C35 expression is persistent throughout tumor progression. Therefore, C35 is considered as an ideal biomarker for the diagnosis of both early-stage and late-stage cancer, and a possible anti-cancer therapeutic target (1, 2)|
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Western blot - XTP4 antibody [EPR2678]; Anti-XTP4 antibody [EPR2678] at 1/1000 dilution + SKBR3 cell lysate at 10 µg.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 12 kDa.Observed band size : 12 kDa.