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Home Antibody All anti-CCND1 antibodies

Anti-CCND1 Antibody SP4

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307019
  • Rabbit monoclonal antibody against Cyclin D1(clone SP4 )
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403284) , 20ug
100ul $379 In Stock
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WB(1)
IHC(2)
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Also for CCND1 (NM_053056)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide from C-terminus of human cyclin D1.
Clone NameSP4 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100; IP: 1:20
BufferPreservative: 0.1% Sodium azide
Constituent: 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens cyclin D1 (CCND1)
Alternative NameBCL1; D11S287E; PRAD1; U21B31
Database LinkNP_444284
FunctionThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq].
Related Pathway
Cell cycle
Focal Adhesion
Jak-STAT signaling pathway
TGF Beta Signaling Pathway
Wnt Signaling Pathway

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WB Image
Western blot - Anti-Cyclin D1 antibody; Anti-Cyclin D1 antibody [SP4] at 1/5000 dilution + MCF7 cell lysate at 10 µg.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 34 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin D1 antibody; Immunohistochemical analysis of paraffin-embedded Human mantle cell lymphoma tissue labelling Cyclin D1 with TA307019 at 1/100.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin D1 antibody [SP4]; Immunohistochemical analysis of Human bladder tumour tissue, staining Cyclin D1 with TA307019. Antigen retrieval was performed by heat mediation in citrate buffer (pH 6), before being incubated with primary antibody (1/100). Staining was detected using DAB.

 

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