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Anti-CCND1 Antibody SP4
Also for CCND1 (NM_053056)
|A synthetic peptide from C-terminus of human cyclin D1.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:100; IP: 1:20
|Preservative: 0.1% Sodium azide|
Constituent: 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or ICC.
|Homo sapiens cyclin D1 (CCND1)|
|BCL1; D11S287E; PRAD1; U21B31|
|The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq]. |
Jak-STAT signaling pathway
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot - Anti-Cyclin D1 antibody; Anti-Cyclin D1 antibody [SP4] at 1/5000 dilution + MCF7 cell lysate at 10 µg.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 34 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin D1 antibody; Immunohistochemical analysis of paraffin-embedded Human mantle cell lymphoma tissue labelling Cyclin D1 with ab137875 at 1/100.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin D1 antibody [SP4]; Immunohistochemical analysis of Human bladder tumour tissue, staining Cyclin D1 with ab137875. Antigen retrieval was performed by heat mediation in citrate buffer (pH 6), before being incubated with primary antibody (1/100). Staining was detected using DAB.