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Anti-LMNA Antibody EPR4100
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Also for LMNA (NM_170707)
|A synthetic peptide corresponding to residues in human Lamin A/C was used as an immunogen.|
||FC: 1:10 - 100, ICC: 1:250 - 500, IHC: 1:250 - 500, IP: 1:10 - 100, WB: 1:10,000-50,000,
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens lamin A/C (LMNA), transcript variant 1|
|CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;|
|The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins makes up the matrix and is highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B (1). By alternate splicing, lamin A/C produces the following three isoforms: isoform A (74 kDa), isoform C (65 kDa), and isoform ADelta10 (70 kDa) (2). Mutations in lamin A/C lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome (1).|
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Western blot analysis on (A) HeLa and (B) SH-SY5Y cell lysates using anti-Lamin A/C RabMAb .
Immunohistochemical staining of paraffin-embedded human liver tissue using anti-Lamin A/C RabMAb .