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Home Antibody All anti-RAB27A antibodies

Anti-RAB27A Antibody EPR3021

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306983 Rabbit monoclonal antibody against RAB27A(clone EPR3021) 100ul $325 2 Weeks
LC405229 RAB27A HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for RAB27A (NM_183234)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RAB27A was used as an immunogen.
Clone NameEPR3021 IsotypeIgG
Species ReactivityRat, Human, Rhesus monkey (Does not react with: Mouse) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:100 - 1:500; ICC/IF: Use at an assay dependent concentration
Predicted MW Explanation 25 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse

Reference Data

Target NameHomo sapiens RAB27A, member RAS oncogene family (RAB27A), transcript variant 2
Alternative NameGS2; HsT18676; RAB27; RAM
Database LinkNP_899057
Entrez Gene 5873 Human
Entrez Gene 50645 Rat
Entrez Gene 697741 Monkey
FunctionRas-related protein (RAB27A), a member of the Ras family, is a GTP-binding protein that is involved in protein transport and small GTPase mediated signal transduction (1). RAB27A plays a role in cytotoxic granule exocytosis in lymphocytes (1). This process is mediated by RAB27A acting as an effector for JFC1/Slp1 and Munc13-4 (2). RAB27A also interacts with Slp4-a (synaptotagmin-like protein4-a) to negatively control dense-core vesicle exocytosis (3). In addition, it is required for granule maturation, granule docking, and priming at the immunologic synapse (1). RAB27A is more restricted in expression than other Ras members; it is highly expressed only in melanocytes, hematopoietic cells, and other secretory cells (4). Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2), which results in an uncontrolled T-lymphocyte and macrophage activation syndrome (1).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

 

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