Ras-related protein (RAB27A), a member of the Ras family, is a GTP-binding protein that is involved in protein transport and small GTPase mediated signal transduction (1). RAB27A plays a role in cytotoxic granule exocytosis in lymphocytes (1). This process is mediated by RAB27A acting as an effector for JFC1/Slp1 and Munc13-4 (2). RAB27A also interacts with Slp4-a (synaptotagmin-like protein4-a) to negatively control dense-core vesicle exocytosis (3). In addition, it is required for granule maturation, granule docking, and priming at the immunologic synapse (1). RAB27A is more restricted in expression than other Ras members; it is highly expressed only in melanocytes, hematopoietic cells, and other secretory cells (4). Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2), which results in an uncontrolled T-lymphocyte and macrophage activation syndrome (1).
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