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Home Antibody All anti-MBNL1 antibodies

Anti-MBNL1 Antibody EPR4565

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306970
  • Rabbit monoclonal antibody against MBNL1(clone EPR4565)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC404079) , 20ug Explanation
100ul $325 In Stock
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WB(1)
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Also for MBNL1 (NM_207296)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MBNL1 was used as an immunogen.
Clone NameEPR4565 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens muscleblind-like splicing regulator 1 (MBNL1), transcript variant 6
Alternative NameEXP; EXP35; EXP40; EXP42; MBNL
Database LinkNP_997179
Entrez Gene 4154 Human
Entrez Gene 56758 Mouse
FunctionMBNL1 is a member of the muscleblind-like (MBNL) family that mediates pre-mRNA alternative splicing regulation (1). MBNL1 acts either as activator or repressor of splicing on specific pre-mRNA targets. It inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. In addition, it antagonizes the alternative splicing activity pattern of CELF proteins, regulates the TNNT2 exon 5 skipping through competition with U2AF2 and inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. It may also play a role in myotonic dystrophy pathophysiology (DM) (2).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Muscleblind-like 1 antibody [EPR4565]; All lanes : Anti-Muscleblind-like 1 antibody [EPR4565] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : A673 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 42 kDa.
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