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Anti-MBNL1 Antibody EPR4565
Also for MBNL1 (NM_207296)
|A synthetic peptide corresponding to residues in human MBNL1 was used as an immunogen.|
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens muscleblind-like splicing regulator 1 (MBNL1), transcript variant 6|
|EXP; EXP35; EXP40; EXP42; MBNL|
Entrez Gene 4154 Human
Entrez Gene 56758 Mouse
|MBNL1 is a member of the muscleblind-like (MBNL) family that mediates pre-mRNA alternative splicing regulation (1). MBNL1 acts either as activator or repressor of splicing on specific pre-mRNA targets. It inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. In addition, it antagonizes the alternative splicing activity pattern of CELF proteins, regulates the TNNT2 exon 5 skipping through competition with U2AF2 and inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. It may also play a role in myotonic dystrophy pathophysiology (DM) (2).|
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Western blot - Muscleblind-like 1 antibody [EPR4565]; All lanes : Anti-Muscleblind-like 1 antibody [EPR4565] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : A673 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 42 kDa.