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Anti-MBNL1 Antibody EPR4565

WB(1)

Gene Name Homo sapiens muscleblind-like splicing regulator 1 (MBNL1), transcript variant 6 Synonyms: EXP; EXP35; EXP40; EXP42; MBNL Immunogen A synthetic peptide corresponding to residues in human MBNL1 was used as an immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name EPR4565 Isotype Rabbit IgG Species Reactivity Human, Mouse Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB Suggested Dilutions WB: 1:1,000 - 10,000, Background MBNL1 is a member of the muscleblind-like (MBNL) family that mediates pre-mRNA alternative splicing regulation (1). MBNL1 acts either as activator or repressor of splicing on specific pre-mRNA targets. It inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. In addition, it antagonizes the alternative splicing activity pattern of CELF proteins, regulates the TNNT2 exon 5 skipping through competition with U2AF2 and inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. It may also play a role in myotonic dystrophy pathophysiology (DM) (2). Related Pathway Adipogenesis

Related Lysate from OriGene • Transient overexpression lysate of muscleblind-like (Drosophila) (MBNL1), transcript variant 6 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • MBNL1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • MBNL1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Mbnl1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • MBNL1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Mbnl1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens muscleblind-like (Drosophila) (MBNL1), transcript variant 6 as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens muscleblind-like (Drosophila) (MBNL1), transcript variant 6 as transfection-ready DNA • Lenti ORF clone of Human muscleblind-like (Drosophila) (MBNL1), transcript variant 6 , Myc-DDK-tagged • Lenti ORF clone of Human muscleblind-like (Drosophila) (MBNL1), transcript variant 6, mGFP tagged Related cDNA Clones • Homo sapiens muscleblind-like (Drosophila) (MBNL1), transcript variant 6 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)