Home Antibody All anti-ANAPC1 antibodies
Also for ANAPC1 (NM_022662)
|APC1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human APC1.|
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens anaphase promoting complex subunit 1 (ANAPC1)|
|APC1; MCPR; TSG24|
Entrez Gene 64682 Human
Entrez Gene 17222 Mouse
|Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.|
|Stem cell - PluripotencyDruggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation|
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Western blot analysis of APC1 in SK-N-SH cell lysate with APC1 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of APC1 in human brain tissue with APC1 antibody at 5 ug/mL.