Home Antibody All anti-EFHD2 antibodies
Also for EFHD2 (NM_024329)
|EFHD2 antibody was raised against a 16 amino acid peptide near the amino terminus of human EFHD2.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens EF-hand domain family, member D2 (EFHD2)|
Entrez Gene 79180 Human
Entrez Gene 27984 Mouse
Entrez Gene 298609 Rat
|EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-kappa-B-activating branch.|
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Western blot analysis of EFHD2 in mouse brain tissue lysate with EFHD2 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of EFHD2 in human brain tissue with EFHD2 antibody at 5 ug/mL.
Immunofluorescence of EFHD2 in human brain tissue with EFHD2 antibody at 20 ug/mL.