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Home Antibody All anti-BCAS2 antibodies

Anti-BCAS2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306932
  • Rabbit Polyclonal BCAS2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417014) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for BCAS2 (NM_005872)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBCAS2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human BCAS2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens breast carcinoma amplified sequence 2 (BCAS2)
Alternative NameDAM1; Snt309; SPF27
Database LinkNP_005863
FunctionBCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53-null or –mutant cells; this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of BCAS2 in MCF7 cell lysate with BCAS2 antibody at (A) 0.5 and (B) 1 ug/mL.
IHC Image
Immunohistochemistry of BCAS2 in human breast carcinoma with BCAS2 antibody at 5 ug/mL.
IF Image
Immunofluorescence of BCAS2 in human breast carcinoma tissue with BCAS2 antibody at 20 ug/mL.

 

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