Home Antibody All anti-TCF3 antibodies
Also for TCF3 (NM_001136139)
|TCF3 antibody was raised against a 17 amino acid peptide near the amino terminus of human TCF3.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens transcription factor 3 (TCF3), transcript variant 2|
|bHLHb21; E2A; E47; ITF1; TCF-3; VDIR|
|The TCF3 gene, also called E2A, encodes two basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. These transcription factors are involved in mediating canonical Wnt signaling, which is very important in a diverse array of cellular functions such as stem cell proliferation, self-renewal, activation, fate determination, differentiation and aging and senescence. They bind beta-catenin and can act as transcriptional activators or repressors for Wnt target genes, and have been shown to regulate specific target genes during CNS development downstream of Wnt signaling. TCF3/Lef complexes are also known to play key roles in controlling cell fate lineages in multipotent skin stem cells.|
Delta-Notch Signaling Pathway
Wnt Signaling Pathway
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Western blot analysis of TCF3 in Human brain tissue lysate with TCF3 antibody at 1 ug/mL in (A) the absence and (B) presence of peptide blocking.
Immunohistochemistry of TCF3 in rat liver tissue with TCF3 antibody at 5 ug/mL.