Home Antibody All anti-GATA3 antibodies
Also for GATA3 (NM_001002295)
|GATA3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human GATA3.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens GATA binding protein 3 (GATA3), transcript variant 1|
Entrez Gene 2625 Human
Entrez Gene 14462 Mouse
Entrez Gene 85471 Rat
|GATA3 is a zinc finger transcription factor that was first recognized as a possible determinant of T cell development. Later studies demonstrated that it is expressed in trophoblast giant cells and regulates trophoblast-specific genes during development. Specifically, GATA3 is selectively expressed in the trophectoderm of the peri-implantation embryo and regulates CDX2, which is required for the transcriptional repression of the POU5F1/Oct4 and NANOG genes and is thus essential for the segregation of the inner cell mass and trophectoderm at the blastocyst stage. Decreased or null-expression expression of GATA3 has also been suggested to play a major role in the development and progression of luminal breast cancer.|
|Stem cell relevant signaling - JAK/STAT signaling pathwayES Cell Differentiation/IPSAdult stem cellsTranscription Factors |
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Western blot analysis of GATA3 in human brain tissue lysate with GATA3 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of GATA3 in rat brain tissue with GATA3 antibody at 2.5 ug/mL.