Home Antibody All anti-BFAR antibodies
Also for BFAR (NM_016561)
|BFAR antibody was raised against a 14 amino acid peptide near the carboxy terminus of human BFAR.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens bifunctional apoptosis regulator (BFAR)|
|The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.|
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Western blot analysis of BFAR in human kidney tissue lysate with BFAR antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of BFAR in mouse kidney tissue with BFAR antibody at 5 ug/mL.
Immunofluorescence of BFAR in mouse kidney tissue with BFAR antibody at 20 ug/mL.