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Home Antibody All anti-NR1H2 antibodies

Anti-NR1H2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306912
  • Rabbit Polyclonal LXR-B Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402093) , 20ug
100ug $325 3-7 Days
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WB(1)
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Also for NR1H2 (NM_007121)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenLXR-B antibody was raised against a 14 amino acid peptide from near the amino terminus human LXR-B.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens nuclear receptor subfamily 1, group H, member 2 (NR1H2), transcript variant 1
Alternative NameLXR-b; LXRB; NER; NER-I; RIP15; UNR
Database LinkNP_009052
FunctionLXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRa, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer’s disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the e3 allele.
Related Pathway

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WB Image
Western blot analysis of LXR-B in human lung tissue lysate with LXR-B antibody at (A) 1 and (B) 2 µg/ml.

 

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