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Home Antibody All anti-TMEM38B antibodies

Anti-TMEM38B Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306889
  • Rabbit Polyclonal TMEM38B Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC413299) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
IF(1)
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Also for TMEM38B (NM_018112)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTMEM38B antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TMEM38B.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens transmembrane protein 38B (TMEM38B)
Alternative NamebA219P18.1; C9orf87; D4Ertd89e; OI14; TRIC-B; TRICB
Database LinkNP_060582
FunctionTMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TMEM38B in rat thymus tissue lysate with TMEM38B antibody at (A) 1 and (B) 2 ug/mL.
IHC Image
Immunohistochemistry of TMEM38B in mouse thymus tissue with TMEM38B antibody at 5 ug/mL.
IF Image
Immunofluorescence of TMEM38B in mouse thymus tissue with TMEM38B antibody at 20 ug/mL.

 

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