Home Antibody All anti-PPAPDC1A antibodies
Also for PPAPDC1A (NM_001030059)
|PPAPDC1A antibody was raised against a 14 amino acid peptide near the carboxy terminus of human PPAPDC1A.|
|Human, Mouse, Rat
||WB: 1 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens phosphatidic acid phosphatase type 2 domain containing 1A (PPAPDC1A)|
Entrez Gene 196051 Human
Entrez Gene 381925 Mouse
Entrez Gene 309014 Rat
|Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide(NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. PPAPDC1A is preferentially expressed in endothelial cells. Studies of PPAPDC1A and PAP activity suggest that they may play a role in angiogenesis.|
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Western blot analysis of PPAPDC1A in human brain tissue lysate with PPAPDC1A antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of PPAPDC1A in human brain tissue with PPAPDC1A antibody at 20 ug/mL.