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Home Antibody All anti-FRMPD2 antibodies

Anti-FRMPD2 Antibody


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SKU Description Amount Price Availability*  
TA306863 Rabbit Polyclonal FRMPD2 Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenFRMPD2 antibody was raised against a 15 amino acid peptide from near the amino terminus of human FRMPD2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/mL, ICC: 5 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameFERM and PDZ domain containing 2
Alternative NamePDZD5C|PDZK4|PDZK5C
Database Link-
Entrez Gene 143162 Human
Entrez Gene 268729 Mouse
Entrez Gene 498583 Rat
FunctionThe FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL (4). FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of FRMPD2 in rat kidney tissue lysate with FRMPD2 antibody at (A) 1 and (B) 2 µg/ml.

IHC Image
Immunohistochemistry of FRMPD2 in mouse kidney tissue with FRMPD2 antibody at 5 ug/ml.


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