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Home Antibody All anti-NDUFAF2 antibodies

Anti-NDUFAF2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306859
  • Rabbit Polyclonal Mimitin Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC406293) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for NDUFAF2 (NM_174889)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenMimitin antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Mimitin.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 (NDUFAF2)
Alternative NameB17.2L; mimitin; MMTN; NDUFA12L
Database LinkNP_777549
FunctionMimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kB-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
Related Pathway

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WB Image
Western blot analysis of Mimitin in Raji cell lysate with Mimitin antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunofluorescence of Mimitin in Raji cells with Mimitin antibody at 20 ug/mL.

 

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