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Home Antibody All anti-GOLPH3 antibodies

Anti-GOLPH3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306858
  • Rabbit Polyclonal GOLPH3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411758) , 20ug
100ug 325 In Stock
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WB(1)
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Also for GOLPH3 (NM_022130)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenGOLPH3 antibody was raised against a 14 amino acid peptide from near the amino terminus of human GOLPH3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens golgi phosphoprotein 3 (coat-protein) (GOLPH3)
Alternative NameGOPP1; GPP34; MIDAS
Database LinkNP_071413
FunctionGOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signalling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signalling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.
Related Pathway

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WB Image
Western blot analysis of GOLPH3 in rat lung tissue lysate with GOLPH3 antibody at (A) 0.5 and (B) 1 µg/ml.

 

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