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Home Antibody All anti-ACBD3 antibodies

Anti-ACBD3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306856
  • Rabbit Polyclonal GOLPH1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411600) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for ACBD3 (NM_022735)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenGOLPH1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human GOLPH1.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens acyl-CoA binding domain containing 3 (ACBD3)
Alternative NameGCP60; GOCAP1; GOLPH1; PAP7
Database LinkNP_073572
FunctionGOLPH1, also known as GCP60, was initially identified as a Golgi protein that can interact with the integral membrane protein giantin and is thought to be involved in the maintenance of the Golgi structure. GOLPH1 has also been shown to interact with other Golgi proteins such as Golgin-160, a Golgi protein that can be cleaved by caspases-2, -3, and -7, leading to the nuclear localization of Golgin-160. GOLPH1 interaction with the Golgin-160 fragments is stronger than that with the intact Golgin-160, with its interaction regulated by the oxidation state of Cys-463 within GOLPH1, suggesting that the nuclear localization of the caspase-cleaved Golgin-160 fragments is a highly coordinated event. GOLPH1 has also been found to interact with Numb, a cytosolic signaling protein that mediates asymetric cell division of neural progenitor cells to a daughter progenitor cell and a neuron, suggesting that Golgi fragmentation and reconstitution during the cell cycle differentially regulate Numb signaling through changes in GOLPH1 subcellular distribution and may couple cell fate with cell cycle progression.
Related Pathway

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WB Image
Western blot analysis of GOLPH1 in K562 cell lysate with GOLPH1 antibody at (A) 1 and (B) 2 µg/ml.

 

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