Home Antibody All anti-RUSC1 antibodies
Also for RUSC1 (NM_001105203)
|RUSC1 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human RUSC1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens RUN and SH3 domain containing 1 (RUSC1), transcript variant 1|
Entrez Gene 23623 Human
Entrez Gene 72296 Mouse
|RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IkappaB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-kappaB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappaB activation pathway.|
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Western blot analysis of RUSC1 in A-20 cell lysate with RUSC1 antibody at 1 µg/ml.