Home Antibody All anti-RIPK1 antibodies
Also for RIPK1 (NM_003804)
|RIPK1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human RIPK1.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)|
Entrez Gene 8737 Human
Entrez Gene 19766 Mouse
Entrez Gene 306886 Rat
|RIPK1 (Receptor Interacting Protein) is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIPK1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIPK1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIPK1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIPK1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.|
|Protein KinaseDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway|
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Western blot analysis of RIPK1 in rat kidney tissue lysate with RIPK1 antibody at 1 µg/ml.
Immunohistochemistry of RIPK1 in mouse kidney tissue with RIPK1 antibody at 2.5 ug/ml.