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Home Antibody All anti-JMJD1C antibodies

Anti-JMJD1C Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306830
  • Rabbit Polyclonal JMJD1C Antibody
100ug $325 In Stock
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenJMJD1C antibody was raised against a 20 amino acid peptide from near the amino terminus of human JMJD1C.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens jumonji domain containing 1C (JMJD1C), transcript variant 2
Alternative NameRP11-10C13.2; TRIP8
Database LinkNP_004232
FunctionThe jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist. This antibody will not cross-react with JMJD1A or JMJD1B.
Related Pathway

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WB Image
Western blot analysis of JMJD1C in human liver tissue lysate with JMJD1C antibody at (A) 1 and (B) 2 µg/ml.
IHC Image
Immunohistochemistry of JMJD1C in rat liver tissue with JMJD1C antibody at 2.5 ug/ml.
IF Image
Immunofluorescence of JMJD1C in rat liver tissue with JMJD1C antibody at 20 ug/mL.

 

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