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Home Antibody All anti-KDM3B antibodies

Anti-KDM3B Antibody

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SKU Description Amount Price Availability*  
TA306829 Rabbit Polyclonal JMJD1B Antibody 100ug $325 3-7 Days
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenJMJD1B antibody was raised against a 20 amino acid peptide from near the center of human JMJD1B.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens lysine (K)-specific demethylase 3B (KDM3B)
Alternative Name5qNCA; C5orf7; JMJD1B; NET22
Database LinkNP_057688
Entrez Gene 51780 Human
Entrez Gene 277250 Mouse
Entrez Gene 682469 Rat
FunctionThe jumonji domain containing 1B protein (JMJD1B) was originally discovered as a candidate for the myeloid leukemia tumor suppressor gene. Besides CD34+ cells and acute myeloid leukemia (AML) cell lines, JMJD1B mRNA is highly expressed in liver, heart, kidney, skeletal muscle, and placenta tissues. The JMJD1B gene is localized to a region of chromosome 5q31, which is frequently deleted in myeloid leukemias and myelodysplasias and expression of JMJD1B in a del(5q) cell line results in suppression of clonogenic growth suggesting that JMJD1B may function as a tumor suppressor. In contrast, JMJD1B gene copy number and mRNA expression level was increased in several non-small cell lung cancers indicating that the role of JMJD1B in cancer formation and progression is more complex than originally postulated. At least three isoforms of JMJD1B are known to exist. This antibody will not cross-react with JMJD1A or JMJD1C.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of JMJD1B in rat liver tissue lysate with JMJD1B antibody at (A) 1 and (B) 2 µg/ml.
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Immunohistochemistry of JMJD1B in rat liver tissue with JMJD1B antibody at 2.5 ug/ml.
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Immunofluorescence of JMJD1B in rat liver tissue with JMJD1B antibody at 20 ug/mL.
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