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Home Antibody All anti-FAM120A antibodies

Anti-FAM120A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306826
  • Rabbit Polyclonal FAM120A Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415164) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for FAM120A (NM_014612)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFAM120A antibody was raised against an 18 amino acid peptide from near the center of human FAM120A.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens family with sequence similarity 120A (FAM120A), transcript variant 1
Alternative NameC9orf10; DNAPTP1; DNAPTP5; OSSA
Database LinkNP_055427
FunctionFAM120A (C9orf10) is a member of the constitutive coactivator of PPAR gamma family and the gene was mapped to chromosome 9q22.31. FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells. This antibody will not cross-reacti with FAM120B / PGCC1.
Related Pathway

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WB Image
Western blot analysis of FAM120A in SK-N-SH cell lysate with FAM120A antibody at (A) 0.5 and (B) 1 µg/ml.
IHC Image
Immunohistochemistry of FAM120A in rat brain tissue with FAM120A antibody at 2.5 ug/ml.

 

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