Home Antibody All anti-SYPL2 antibodies
Also for SYPL2 (NM_001006603)
|SYPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human SYPL.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens synaptophysin-like 2 (SYPL2)|
|MG29; OTTHUMP00000012638; mitsugumin 29; mitsugumin-29; synaptophysin-like 2|
|SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores. At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.|
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Western blot analysis of SYPL2 in human spleen tissue lysate with SYPL2 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of SYPL2 in human spleen tissue with SYPL2 antibody at 2.5 ug/ml.