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Home Antibody All anti-HAAO antibodies

Anti-HAAO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306802
  • Rabbit Polyclonal HAAO Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415914) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for HAAO (NM_012205)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenHAAO antibody was raised against a 17 amino acid peptide near the amino terminus of human HAAO.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens 3-hydroxyanthranilate 3,4-dioxygenase (HAAO)
Alternative Name3-HAO; HAO
Database LinkNP_036337
FunctionHAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of HAAO in Mouse liver tissue lysate with HAAO antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of HAAO in human liver tissue with HAAO antibody at 2.5 ug/ml.

 

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