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Anti-HAAO Antibody

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	HAAO antibody was raised against a 17 amino acid peptide near the amino terminus of human HAAO.
Clone Name		Isotype	IgG
Species Reactivity	Human, Mouse, Rat	Concentration	1ug/ul
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1 - 2 ug/ml
Buffer	PBS containing 0.02% sodium azide.
Purification	Affinity chromatography purified via peptide column (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens 3-hydroxyanthranilate 3,4-dioxygenase (HAAO)
Alternative Name	3-HAO; HAO
Database Link	NP_036337
Function	HAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • HAAO - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • HAAO - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Haao - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • HAAO - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Haao - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) as transfection-ready DNA • Lenti ORF clone of Human 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) , Myc-DDK-tagged • Lenti ORF clone of Human 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), mGFP tagged • GFP-tagged ORF clone of Homo sapiens 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) as transfection-ready DNA Related cDNA Clones • Homo sapiens 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)