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Home Antibody All anti-THEM4 antibodies

Anti-THEM4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306801
  • Rabbit Polyclonal THEM4 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403283) , 20ug
100ug $325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for THEM4 (NM_053055)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTHEM4 antibody was raised against an 18 amino acid peptide near the center of human THEM4.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens thioesterase superfamily member 4 (THEM4)
Alternative NameCTMP
Database LinkNP_444283
FunctionTHEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program. The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.
Related Pathway

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WB Image
Western blot analysis of THEM4 in human liver tissue lysate with THEM4 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of THEM4 in human liver tissue with THEM4 antibody at 2.5 ug/ml.
IF Image
Immunofluorescence of THEM4 in human liver tissue with THEM4 antibody at 20 ug/mL.

 

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