Home Antibody All anti-EFEMP1 antibodies
Also for EFEMP1 (NM_001039348)
|Fibulin 3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human Fibulin 3.|
|Human, Mouse, Rat
||ELISA, WB: 0.5 - 1 ug/ml, ICC: 20 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens EGF containing fibulin-like extracellular matrix protein 1 (EFEMP1), transcript variant 2|
|DHRD; DRAD; FBLN3; FBNL; FIBL-3; MLVT; MTLV; S1-5|
|Fibulin 3, also known as epidermal growth factor (EGF)-containing fibulin-like extracellular matrix protein 1 (EFEMP1), is a member of the fibulin family of extracellular glycoproteins, a group of proteins that are widely distributed and frequently associated with vascular and elastic tissues. The fibulin proteins typically contain a tandem array of EGF-like repeats and a fibulin-type COOH-terminal module. Aberrant accumulation of Fibulin 3 in the endoplasmic reticulum of retinal pigment epithelial cells has been shown to be associated with inherited forms of macular degeneration, but the loss of Fibulin 3 expression does not lead to macular degeneration but rather the appearance of hernias due to a reduction of elastic fibers of fascial connective tissue. Recent experiments have shown that expression of Fibulin 3 promotes tumor growth and may thus be a therapeutic target. At least three isoforms of Fibulin 3 are known to exist. This antibody is predicted to not cross-react with other Fibulin proteins.|
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Western blot analysis of Fibulin 3 in HeLa cell lysate with Fibulin 3 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunocytochemistry of Fibulin 3 in HeLa cells with Fibulin 3 antibody at 20 ug/mL.