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Home Antibody All anti-MACC1 antibodies

Anti-MACC1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306790
  • Rabbit Polyclonal MACC1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC405333) , 20ug
100ug $325 In Stock
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WB(1)
IHC(1)
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Also for MACC1 (NM_182762)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenMACC1 antibody was raised against a 17 amino acid peptide near the center of human MACC1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1-2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens metastasis associated in colon cancer 1 (MACC1)
Alternative Name7A5; SH3BP4L
Database LinkNP_877439
FunctionMetastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
Related Pathway

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WB Image
Western blot analysis of MACC1 in mouse liver tissue lysate with MACC1 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of MACC1 in human liver tissue with MACC1 antibody at 2.5 ug/ml.

 

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