Home Antibody All anti-LDLR antibodies
Also for LDLR (NM_000527)
|LDL-R antibody was raised against an 18 amino acid peptide near the center of human LDL-R.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens low density lipoprotein receptor (LDLR), transcript variant 1|
|FH; FHC; LDLCQ2|
Entrez Gene 3949 Human
Entrez Gene 16835 Mouse
Entrez Gene 300438 Rat
|The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.|
|ES Cell Differentiation/IPSTransmembraneDruggable Genome Endocytosis|
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Western blot analysis of LDL-R in human liver tissue lysate with LDL-R antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of LDL-R in human liver tissue with LDL-R antibody at 2.5 ug/ml.