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Home Antibody All anti-LDLR antibodies

Anti-LDLR Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306778 Chicken Polyclonal LDL-R Antibody 100ug $325 In Stock
LC400183 LDLR HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenLDL-R antibody was raised against an 18 amino acid peptide near the center of human LDL-R.
Clone Name IsotypeIgY
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens low density lipoprotein receptor (LDLR), transcript variant 1
Alternative NameFH; FHC; LDLCQ2
Database LinkNP_000518
Entrez Gene 3949 Human
Entrez Gene 16835 Mouse
Entrez Gene 300438 Rat
FunctionThe low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome Endocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of LDL-R in human liver tissue lysate with LDL-R antibody at (A) 1 and (B) 2 ug/ml.
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Immunohistochemistry of LDL-R in human liver tissue with LDL-R antibody at 2.5 ug/ml.
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