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Home Antibody All anti-ERBB2 antibodies

Anti-ERBB2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306774
  • Chicken Polyclonal erbB-2 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC423666) , 20ug
100ug $325 3-7 Days
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WB(1)
IHC(1)
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Also for ERBB2 (NM_001005862)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenerbB-2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human erbB-2.
Clone Name IsotypeIgY
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 2
Alternative NameCD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Database LinkNP_001005862
FunctionThe ErbB family consists of four closely related tyrosine kinase receptors that act as potent mediators of normal cell growth and development. Aberrant expression or function of one or more of these receptors can play a major role in the development and evolution of cancer. ErbB-2, also known as HER2, has been implicated in the evolution of both breast and gastric cancers, and is evident in other cancer types such as ovarian and salivary gland tumors. ErbB-2 possesses an active tyrosine kinase domain, but no direct ligand has been identified yet. ErbB-2 is the preferred binding partner to the other members of the ErbB family and is thought to act primarily through the Ras-MAPK, PI3k-PKB/Akt, and PLC-PKC signaling pathways. Numerous anti-cancer strategies have been employed against erbB-2, such as antibody-based therapies to prevent ligand binding or receptor activation through dimerization, antibody-dependent cell mediated cytotoxicity, in addition to direct kinase inhibition to prevent molecular activation/downstream signaling.
Related Pathway
Adherens junction
Focal Adhesion

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WB Image
Western blot analysis of erbB-2 in rat liver tissue lysate with erbB-2 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of erbB-2 in human liver tissue with erbB-2 antibody at 2.5 ug/ml.

 

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