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Home Antibody All anti-APP antibodies

Anti-APP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306763
  • Rabbit Polyclonal APP Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424694) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenAPP antibody was raised against an 18 amino acid peptide near the amino terminus of human APP.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1
Alternative NameAAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Database LinkNP_000475
FunctionAccumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for ?-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer’s disease patients’ brains. Recently, Death Receptor 6 (DR6) was found to interact with an amino-terminal fragment of the Beta-amyloid protein (N-APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning during development, suggesting that these two proteins are involved in neural development and may possibly play a role in Alzheimer’s disease.
Related Pathway
Delta-Notch Signaling Pathway
Hemostasis

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WB Image
Western blot analysis of APP in mouse brain tissue lysate with APP antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of APP in mouse brain tissue with APP antibody at 2.5 ug/ml.

 

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