Home Antibody All anti-ZBED1 antibodies
Also for ZBED1 (NM_001171135)
|ZBED1 antibody was raised against a 15 amino acid peptide from near the center of human ZBED1.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens zinc finger, BED-type containing 1 (ZBED1), transcript variant 3|
|ALTE; DREF; hDREF; TRAMP|
|ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding. This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.|
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Western blot analysis of ZBED1 in A549 cell lysate with ZBED1 antibody at 1 µg/ml.